PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Brassica napus
M-type_MADS Family
Species TF ID Description
GSBRNA2T00000265001M-type_MADS family protein
GSBRNA2T00001444001M-type_MADS family protein
GSBRNA2T00001450001M-type_MADS family protein
GSBRNA2T00001451001M-type_MADS family protein
GSBRNA2T00005560001M-type_MADS family protein
GSBRNA2T00005999001M-type_MADS family protein
GSBRNA2T00007474001M-type_MADS family protein
GSBRNA2T00007507001M-type_MADS family protein
GSBRNA2T00009799001M-type_MADS family protein
GSBRNA2T00013557001M-type_MADS family protein
GSBRNA2T00013704001M-type_MADS family protein
GSBRNA2T00014621001M-type_MADS family protein
GSBRNA2T00015062001M-type_MADS family protein
GSBRNA2T00015324001M-type_MADS family protein
GSBRNA2T00015742001M-type_MADS family protein
GSBRNA2T00016259001M-type_MADS family protein
GSBRNA2T00017238001M-type_MADS family protein
GSBRNA2T00017641001M-type_MADS family protein
GSBRNA2T00019704001M-type_MADS family protein
GSBRNA2T00022341001M-type_MADS family protein
GSBRNA2T00022419001M-type_MADS family protein
GSBRNA2T00025435001M-type_MADS family protein
GSBRNA2T00026989001M-type_MADS family protein
GSBRNA2T00027140001M-type_MADS family protein
GSBRNA2T00028070001M-type_MADS family protein
GSBRNA2T00028329001M-type_MADS family protein
GSBRNA2T00028815001M-type_MADS family protein
GSBRNA2T00028881001M-type_MADS family protein
GSBRNA2T00029566001M-type_MADS family protein
GSBRNA2T00029966001M-type_MADS family protein
GSBRNA2T00030112001M-type_MADS family protein
GSBRNA2T00033125001M-type_MADS family protein
GSBRNA2T00034591001M-type_MADS family protein
GSBRNA2T00035003001M-type_MADS family protein
GSBRNA2T00035638001M-type_MADS family protein
GSBRNA2T00037849001M-type_MADS family protein
GSBRNA2T00037853001M-type_MADS family protein
GSBRNA2T00038534001M-type_MADS family protein
GSBRNA2T00038536001M-type_MADS family protein
GSBRNA2T00038753001M-type_MADS family protein
GSBRNA2T00039065001M-type_MADS family protein
GSBRNA2T00040524001M-type_MADS family protein
GSBRNA2T00041524001M-type_MADS family protein
GSBRNA2T00042622001M-type_MADS family protein
GSBRNA2T00042625001M-type_MADS family protein
GSBRNA2T00043985001M-type_MADS family protein
GSBRNA2T00046305001M-type_MADS family protein
GSBRNA2T00046841001M-type_MADS family protein
GSBRNA2T00047863001M-type_MADS family protein
GSBRNA2T00048692001M-type_MADS family protein
GSBRNA2T00049567001M-type_MADS family protein
GSBRNA2T00050349001M-type_MADS family protein
GSBRNA2T00052639001M-type_MADS family protein
GSBRNA2T00052939001M-type_MADS family protein
GSBRNA2T00054797001M-type_MADS family protein
GSBRNA2T00055802001M-type_MADS family protein
GSBRNA2T00058691001M-type_MADS family protein
GSBRNA2T00059241001M-type_MADS family protein
GSBRNA2T00059736001M-type_MADS family protein
GSBRNA2T00060000001M-type_MADS family protein
GSBRNA2T00060837001M-type_MADS family protein
GSBRNA2T00062587001M-type_MADS family protein
GSBRNA2T00062655001M-type_MADS family protein
GSBRNA2T00062664001M-type_MADS family protein
GSBRNA2T00064764001M-type_MADS family protein
GSBRNA2T00066453001M-type_MADS family protein
GSBRNA2T00066948001M-type_MADS family protein
GSBRNA2T00067587001M-type_MADS family protein
GSBRNA2T00069341001M-type_MADS family protein
GSBRNA2T00069732001M-type_MADS family protein
GSBRNA2T00070348001M-type_MADS family protein
GSBRNA2T00070528001M-type_MADS family protein
GSBRNA2T00071428001M-type_MADS family protein
GSBRNA2T00072693001M-type_MADS family protein
GSBRNA2T00074410001M-type_MADS family protein
GSBRNA2T00075636001M-type_MADS family protein
GSBRNA2T00078618001M-type_MADS family protein
GSBRNA2T00079250001M-type_MADS family protein
GSBRNA2T00080526001M-type_MADS family protein
GSBRNA2T00080532001M-type_MADS family protein
GSBRNA2T00080930001M-type_MADS family protein
GSBRNA2T00080958001M-type_MADS family protein
GSBRNA2T00081607001M-type_MADS family protein
GSBRNA2T00083353001M-type_MADS family protein
GSBRNA2T00088161001M-type_MADS family protein
GSBRNA2T00090015001M-type_MADS family protein
GSBRNA2T00091115001M-type_MADS family protein
GSBRNA2T00091140001M-type_MADS family protein
GSBRNA2T00093550001M-type_MADS family protein
GSBRNA2T00093623001M-type_MADS family protein
GSBRNA2T00096909001M-type_MADS family protein
GSBRNA2T00097034001M-type_MADS family protein
GSBRNA2T00097199001M-type_MADS family protein
GSBRNA2T00097714001M-type_MADS family protein
GSBRNA2T00099551001M-type_MADS family protein
GSBRNA2T00101166001M-type_MADS family protein
GSBRNA2T00101318001M-type_MADS family protein
GSBRNA2T00102917001M-type_MADS family protein
GSBRNA2T00103329001M-type_MADS family protein
GSBRNA2T00104403001M-type_MADS family protein
GSBRNA2T00107040001M-type_MADS family protein
GSBRNA2T00107626001M-type_MADS family protein
GSBRNA2T00108592001M-type_MADS family protein
GSBRNA2T00108890001M-type_MADS family protein
GSBRNA2T00108894001M-type_MADS family protein
GSBRNA2T00110225001M-type_MADS family protein
GSBRNA2T00111100001M-type_MADS family protein
GSBRNA2T00111307001M-type_MADS family protein
GSBRNA2T00111848001M-type_MADS family protein
GSBRNA2T00115333001M-type_MADS family protein
GSBRNA2T00117394001M-type_MADS family protein
GSBRNA2T00118568001M-type_MADS family protein
GSBRNA2T00118767001M-type_MADS family protein
GSBRNA2T00119499001M-type_MADS family protein
GSBRNA2T00119723001M-type_MADS family protein
GSBRNA2T00120014001M-type_MADS family protein
GSBRNA2T00120181001M-type_MADS family protein
GSBRNA2T00120454001M-type_MADS family protein
GSBRNA2T00120455001M-type_MADS family protein
GSBRNA2T00120482001M-type_MADS family protein
GSBRNA2T00127197001M-type_MADS family protein
GSBRNA2T00127199001M-type_MADS family protein
GSBRNA2T00127201001M-type_MADS family protein
GSBRNA2T00127202001M-type_MADS family protein
GSBRNA2T00127904001M-type_MADS family protein
GSBRNA2T00131136001M-type_MADS family protein
GSBRNA2T00132707001M-type_MADS family protein
GSBRNA2T00133354001M-type_MADS family protein
GSBRNA2T00133701001M-type_MADS family protein
GSBRNA2T00133705001M-type_MADS family protein
GSBRNA2T00134672001M-type_MADS family protein
GSBRNA2T00136207001M-type_MADS family protein
GSBRNA2T00136331001M-type_MADS family protein
GSBRNA2T00136639001M-type_MADS family protein
GSBRNA2T00136760001M-type_MADS family protein
GSBRNA2T00139571001M-type_MADS family protein
GSBRNA2T00142938001M-type_MADS family protein
GSBRNA2T00143077001M-type_MADS family protein
GSBRNA2T00143104001M-type_MADS family protein
GSBRNA2T00144321001M-type_MADS family protein
GSBRNA2T00144356001M-type_MADS family protein
GSBRNA2T00147709001M-type_MADS family protein
GSBRNA2T00147713001M-type_MADS family protein
GSBRNA2T00147933001M-type_MADS family protein
GSBRNA2T00153974001M-type_MADS family protein
GSBRNA2T00154523001M-type_MADS family protein
GSBRNA2T00156356001M-type_MADS family protein
GSBRNA2T00156370001M-type_MADS family protein
GSBRNA2T00156405001M-type_MADS family protein
GSBRNA2T00156464001M-type_MADS family protein
GSBRNA2T00156465001M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513