PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Brassica napus
HD-ZIP Family
Species TF ID Description
GSBRNA2T00130028001HD-ZIP family protein
GSBRNA2T00062739001HD-ZIP family protein
GSBRNA2T00089246001HD-ZIP family protein
GSBRNA2T00079521001HD-ZIP family protein
GSBRNA2T00089400001HD-ZIP family protein
GSBRNA2T00066551001HD-ZIP family protein
GSBRNA2T00032864001HD-ZIP family protein
GSBRNA2T00078194001HD-ZIP family protein
GSBRNA2T00134448001HD-ZIP family protein
GSBRNA2T00032865001HD-ZIP family protein
GSBRNA2T00041300001HD-ZIP family protein
GSBRNA2T00008147001HD-ZIP family protein
GSBRNA2T00142496001HD-ZIP family protein
GSBRNA2T00135548001HD-ZIP family protein
GSBRNA2T00136181001HD-ZIP family protein
GSBRNA2T00049804001HD-ZIP family protein
GSBRNA2T00107061001HD-ZIP family protein
GSBRNA2T00097934001HD-ZIP family protein
GSBRNA2T00064137001HD-ZIP family protein
GSBRNA2T00092275001HD-ZIP family protein
GSBRNA2T00127452001HD-ZIP family protein
GSBRNA2T00131207001HD-ZIP family protein
GSBRNA2T00121635001HD-ZIP family protein
GSBRNA2T00064762001HD-ZIP family protein
GSBRNA2T00022200001HD-ZIP family protein
GSBRNA2T00067972001HD-ZIP family protein
GSBRNA2T00055805001HD-ZIP family protein
GSBRNA2T00092034001HD-ZIP family protein
GSBRNA2T00149729001HD-ZIP family protein
GSBRNA2T00017337001HD-ZIP family protein
GSBRNA2T00082557001HD-ZIP family protein
GSBRNA2T00086174001HD-ZIP family protein
GSBRNA2T00140440001HD-ZIP family protein
GSBRNA2T00150974001HD-ZIP family protein
GSBRNA2T00121502001HD-ZIP family protein
GSBRNA2T00063218001HD-ZIP family protein
GSBRNA2T00037358001HD-ZIP family protein
GSBRNA2T00131048001HD-ZIP family protein
GSBRNA2T00100145001HD-ZIP family protein
GSBRNA2T00155536001HD-ZIP family protein
GSBRNA2T00044984001HD-ZIP family protein
GSBRNA2T00072573001HD-ZIP family protein
GSBRNA2T00073557001HD-ZIP family protein
GSBRNA2T00058728001HD-ZIP family protein
GSBRNA2T00116650001HD-ZIP family protein
GSBRNA2T00003439001HD-ZIP family protein
GSBRNA2T00151088001HD-ZIP family protein
GSBRNA2T00131169001HD-ZIP family protein
GSBRNA2T00067671001HD-ZIP family protein
GSBRNA2T00132920001HD-ZIP family protein
GSBRNA2T00027215001HD-ZIP family protein
GSBRNA2T00057837001HD-ZIP family protein
GSBRNA2T00058501001HD-ZIP family protein
GSBRNA2T00073178001HD-ZIP family protein
GSBRNA2T00031269001HD-ZIP family protein
GSBRNA2T00072357001HD-ZIP family protein
GSBRNA2T00049841001HD-ZIP family protein
GSBRNA2T00041004001HD-ZIP family protein
GSBRNA2T00098554001HD-ZIP family protein
GSBRNA2T00083977001HD-ZIP family protein
GSBRNA2T00007811001HD-ZIP family protein
GSBRNA2T00042542001HD-ZIP family protein
GSBRNA2T00128798001HD-ZIP family protein
GSBRNA2T00046175001HD-ZIP family protein
GSBRNA2T00149282001HD-ZIP family protein
GSBRNA2T00098448001HD-ZIP family protein
GSBRNA2T00134935001HD-ZIP family protein
GSBRNA2T00128889001HD-ZIP family protein
GSBRNA2T00069573001HD-ZIP family protein
GSBRNA2T00127041001HD-ZIP family protein
GSBRNA2T00037243001HD-ZIP family protein
GSBRNA2T00028477001HD-ZIP family protein
GSBRNA2T00016893001HD-ZIP family protein
GSBRNA2T00020577001HD-ZIP family protein
GSBRNA2T00022771001HD-ZIP family protein
GSBRNA2T00004998001HD-ZIP family protein
GSBRNA2T00039661001HD-ZIP family protein
GSBRNA2T00033492001HD-ZIP family protein
GSBRNA2T00049301001HD-ZIP family protein
GSBRNA2T00134287001HD-ZIP family protein
GSBRNA2T00010767001HD-ZIP family protein
GSBRNA2T00119617001HD-ZIP family protein
GSBRNA2T00032256001HD-ZIP family protein
GSBRNA2T00136430001HD-ZIP family protein
GSBRNA2T00001896001HD-ZIP family protein
GSBRNA2T00136429001HD-ZIP family protein
GSBRNA2T00108336001HD-ZIP family protein
GSBRNA2T00074017001HD-ZIP family protein
GSBRNA2T00090670001HD-ZIP family protein
GSBRNA2T00117057001HD-ZIP family protein
GSBRNA2T00053887001HD-ZIP family protein
GSBRNA2T00084516001HD-ZIP family protein
GSBRNA2T00116514001HD-ZIP family protein
GSBRNA2T00103134001HD-ZIP family protein
GSBRNA2T00107191001HD-ZIP family protein
GSBRNA2T00091138001HD-ZIP family protein
GSBRNA2T00088515001HD-ZIP family protein
GSBRNA2T00041455001HD-ZIP family protein
GSBRNA2T00041330001HD-ZIP family protein
GSBRNA2T00019880001HD-ZIP family protein
GSBRNA2T00040175001HD-ZIP family protein
GSBRNA2T00102426001HD-ZIP family protein
GSBRNA2T00131362001HD-ZIP family protein
GSBRNA2T00072405001HD-ZIP family protein
GSBRNA2T00022091001HD-ZIP family protein
GSBRNA2T00099137001HD-ZIP family protein
GSBRNA2T00132125001HD-ZIP family protein
GSBRNA2T00151602001HD-ZIP family protein
GSBRNA2T00086287001HD-ZIP family protein
GSBRNA2T00122062001HD-ZIP family protein
GSBRNA2T00106768001HD-ZIP family protein
GSBRNA2T00156948001HD-ZIP family protein
GSBRNA2T00015660001HD-ZIP family protein
GSBRNA2T00094475001HD-ZIP family protein
GSBRNA2T00126794001HD-ZIP family protein
GSBRNA2T00037385001HD-ZIP family protein
GSBRNA2T00112150001HD-ZIP family protein
GSBRNA2T00093202001HD-ZIP family protein
GSBRNA2T00031829001HD-ZIP family protein
GSBRNA2T00157869001HD-ZIP family protein
GSBRNA2T00153520001HD-ZIP family protein
GSBRNA2T00054659001HD-ZIP family protein
GSBRNA2T00131633001HD-ZIP family protein
GSBRNA2T00098329001HD-ZIP family protein
GSBRNA2T00123560001HD-ZIP family protein
GSBRNA2T00081269001HD-ZIP family protein
GSBRNA2T00040012001HD-ZIP family protein
GSBRNA2T00141380001HD-ZIP family protein
GSBRNA2T00088471001HD-ZIP family protein
GSBRNA2T00050237001HD-ZIP family protein
GSBRNA2T00082469001HD-ZIP family protein
GSBRNA2T00099053001HD-ZIP family protein
GSBRNA2T00077008001HD-ZIP family protein
GSBRNA2T00113748001HD-ZIP family protein
GSBRNA2T00031186001HD-ZIP family protein
GSBRNA2T00116732001HD-ZIP family protein
GSBRNA2T00110242001HD-ZIP family protein
GSBRNA2T00050672001HD-ZIP family protein
GSBRNA2T00029833001HD-ZIP family protein
GSBRNA2T00088278001HD-ZIP family protein
GSBRNA2T00098397001HD-ZIP family protein
GSBRNA2T00114236001HD-ZIP family protein
GSBRNA2T00006095001HD-ZIP family protein
GSBRNA2T00006410001HD-ZIP family protein
GSBRNA2T00061232001HD-ZIP family protein
GSBRNA2T00099502001HD-ZIP family protein
GSBRNA2T00085621001HD-ZIP family protein
GSBRNA2T00089143001HD-ZIP family protein
GSBRNA2T00049089001HD-ZIP family protein
GSBRNA2T00107329001HD-ZIP family protein
GSBRNA2T00047098001HD-ZIP family protein
GSBRNA2T00007629001HD-ZIP family protein
GSBRNA2T00047827001HD-ZIP family protein
GSBRNA2T00139656001HD-ZIP family protein
GSBRNA2T00126997001HD-ZIP family protein
GSBRNA2T00074265001HD-ZIP family protein
GSBRNA2T00006479001HD-ZIP family protein
GSBRNA2T00034870001HD-ZIP family protein
GSBRNA2T00102644001HD-ZIP family protein
GSBRNA2T00102965001HD-ZIP family protein
GSBRNA2T00076691001HD-ZIP family protein
GSBRNA2T00000842001HD-ZIP family protein
GSBRNA2T00103415001HD-ZIP family protein
GSBRNA2T00034871001HD-ZIP family protein
GSBRNA2T00115637001HD-ZIP family protein
GSBRNA2T00128705001HD-ZIP family protein
GSBRNA2T00054740001HD-ZIP family protein
GSBRNA2T00143159001HD-ZIP family protein
GSBRNA2T00094860001HD-ZIP family protein
GSBRNA2T00114865001HD-ZIP family protein
GSBRNA2T00011247001HD-ZIP family protein
GSBRNA2T00076109001HD-ZIP family protein
GSBRNA2T00068309001HD-ZIP family protein
GSBRNA2T00017268001HD-ZIP family protein
GSBRNA2T00081105001HD-ZIP family protein
GSBRNA2T00074541001HD-ZIP family protein
GSBRNA2T00015423001HD-ZIP family protein
GSBRNA2T00094107001HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401