PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Brachypodium distachyon
HD-ZIP Family
Species TF ID Description
Bradi4g32737.1.pHD-ZIP family protein
Bradi3g38600.1.pHD-ZIP family protein
Bradi3g56180.2.pHD-ZIP family protein
Bradi3g56180.3.pHD-ZIP family protein
Bradi3g56180.1.pHD-ZIP family protein
Bradi3g35850.1.pHD-ZIP family protein
Bradi1g73190.1.pHD-ZIP family protein
Bradi3g37810.1.pHD-ZIP family protein
Bradi3g33410.1.pHD-ZIP family protein
Bradi5g17570.1.pHD-ZIP family protein
Bradi4g31690.1.pHD-ZIP family protein
Bradi1g71930.1.pHD-ZIP family protein
Bradi1g69150.1.pHD-ZIP family protein
Bradi3g21480.1.pHD-ZIP family protein
Bradi5g17170.2.pHD-ZIP family protein
Bradi4g29380.1.pHD-ZIP family protein
Bradi1g51270.1.pHD-ZIP family protein
Bradi1g51257.3.pHD-ZIP family protein
Bradi3g50220.1.pHD-ZIP family protein
Bradi3g46320.6.pHD-ZIP family protein
Bradi4g35910.1.pHD-ZIP family protein
Bradi3g46320.5.pHD-ZIP family protein
Bradi2g45000.1.pHD-ZIP family protein
Bradi3g46320.2.pHD-ZIP family protein
Bradi3g46320.3.pHD-ZIP family protein
Bradi3g46320.4.pHD-ZIP family protein
Bradi1g23460.1.pHD-ZIP family protein
Bradi1g33870.2.pHD-ZIP family protein
Bradi1g71280.2.pHD-ZIP family protein
Bradi3g03970.1.pHD-ZIP family protein
Bradi3g03970.2.pHD-ZIP family protein
Bradi1g33870.3.pHD-ZIP family protein
Bradi1g71280.1.pHD-ZIP family protein
Bradi3g15327.3.pHD-ZIP family protein
Bradi3g15327.1.pHD-ZIP family protein
Bradi3g15327.2.pHD-ZIP family protein
Bradi5g22570.1.pHD-ZIP family protein
Bradi5g22570.2.pHD-ZIP family protein
Bradi5g22570.3.pHD-ZIP family protein
Bradi3g51540.1.pHD-ZIP family protein
Bradi3g51540.4.pHD-ZIP family protein
Bradi1g13910.1.pHD-ZIP family protein
Bradi4g01887.1.pHD-ZIP family protein
Bradi2g06210.1.pHD-ZIP family protein
Bradi3g28970.1.pHD-ZIP family protein
Bradi3g28970.2.pHD-ZIP family protein
Bradi3g14500.1.pHD-ZIP family protein
Bradi3g14500.2.pHD-ZIP family protein
Bradi5g18717.1.pHD-ZIP family protein
Bradi4g35760.1.pHD-ZIP family protein
Bradi5g18717.2.pHD-ZIP family protein
Bradi1g46247.1.pHD-ZIP family protein
Bradi3g57567.2.pHD-ZIP family protein
Bradi3g57567.1.pHD-ZIP family protein
Bradi3g34410.1.pHD-ZIP family protein
Bradi3g34410.2.pHD-ZIP family protein
Bradi2g31600.1.pHD-ZIP family protein
Bradi1g57082.1.pHD-ZIP family protein
Bradi3g23365.1.pHD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401