Plant Transcription Factor Database
Previous version: v1.0, v2.0, v3.0
Arabidopsis thaliana
NF-YC Family
Species TF ID Description
AT1G07980.1nuclear factor Y, subunit C10
AT1G08970.1nuclear factor Y, subunit C9
AT1G08970.2nuclear factor Y, subunit C9
AT1G08970.3nuclear factor Y, subunit C9
AT1G08970.4nuclear factor Y, subunit C9
AT1G54830.1nuclear factor Y, subunit C3
AT1G54830.2nuclear factor Y, subunit C3
AT1G54830.3nuclear factor Y, subunit C3
AT1G56170.1nuclear factor Y, subunit C2
AT1G56170.2nuclear factor Y, subunit C2
AT3G12480.1nuclear factor Y, subunit C11
AT3G48590.1nuclear factor Y, subunit C1
AT5G19490.1NF-YC family protein
AT5G27910.1nuclear factor Y, subunit C8
AT5G38140.1nuclear factor Y, subunit C12
AT5G43250.1nuclear factor Y, subunit C13
AT5G50470.1nuclear factor Y, subunit C7
AT5G50480.1nuclear factor Y, subunit C6
AT5G50490.1nuclear factor Y, subunit C5
AT5G63470.1nuclear factor Y, subunit C4
AT5G63470.2nuclear factor Y, subunit C4
NF-YC Family Introduction

NF-Y transcription factors are likely found in all eukaryotes and have roles in the regulation of diverse genes (McNabb et al., 1995; Edwards et al., 1998; Maity and de Crombrugghe, 1998; Mantovani, 1999). In mammals, where their biochemistry is well described, the NF-Y transcription factor complex is composed of three unique subunits: NF-YA, NF-YB, and NF-YC. Assembly of the NF-Y heterotrimer in mammals follows a strict, stepwise pattern (Sinha et al., 1995, 1996). Initially, a heterodimer is formed in the cytoplasm between the subunits NF-YB and NF-YC. This dimer then translocates to the nucleus, where the third subunit, NF-YA, is recruited to generate the mature, heterotrimeric NF-Y transcription factor (Frontini et al., 2004; Kahle et al., 2005). Mature NF-Y binds promoters with the core pentamer nucleotide sequence CCAAT, and this can result in either positive or negative transcriptional regulation(Peng and Jahroudi, 2002, 2003; Ceribelli et al., 2008).

As with NF-YA, NF-YB and NF-YC families have well-described subunit interaction and DNA-binding domains ( Kim et al., 1996; Sinha et al., 1996; McNabb et al., 1997; Romier et al., 2003). The conserved regions of NF-YB and NF-YC have structural and amino acid homology to histone fold motifs. Specifically, NF-YB is related to the histone fold motifs of H2B histones, while NF-YC subunits are related to H2A histones (Mantovani, 1999).

Siefers N, Dang KK, Kumimoto RW, Bynum WE 4th, Tayrose G, Holt BF 3rd.
Tissue-specific expression patterns of Arabidopsis NF-Y transcription factors suggest potential for extensive combinatorial complexity.
Plant Physiol, 2009. 149(2): p. 625-41.
PMID: 19019982