Plant Transcription Factor Database
Previous version: v1.0, v2.0, v3.0
Arabidopsis thaliana
Species TF ID Description
AT1G22130.1AGAMOUS-like 104
AT1G24260.1MIKC_MADS family protein
AT1G24260.2MIKC_MADS family protein
AT1G24260.3MIKC_MADS family protein
AT1G26310.1MIKC_MADS family protein
AT1G69120.1MIKC_MADS family protein
AT1G71692.1AGAMOUS-like 12
AT1G77080.2MIKC_MADS family protein
AT1G77080.4MIKC_MADS family protein
AT1G77080.5MIKC_MADS family protein
AT1G77950.1AGAMOUS-like 67
AT1G77950.2AGAMOUS-like 67
AT1G77980.1AGAMOUS-like 66
AT2G03710.1MIKC_MADS family protein
AT2G03710.2MIKC_MADS family protein
AT2G03710.3MIKC_MADS family protein
AT2G14210.1AGAMOUS-like 44
AT2G22540.1MIKC_MADS family protein
AT2G22540.2MIKC_MADS family protein
AT2G22630.1AGAMOUS-like 17
AT2G42830.1MIKC_MADS family protein
AT2G42830.2MIKC_MADS family protein
AT2G45650.1AGAMOUS-like 6
AT2G45660.1AGAMOUS-like 20
AT3G02310.1MIKC_MADS family protein
AT3G30260.1AGAMOUS-like 79
AT3G54340.1MIKC_MADS family protein
AT3G57230.1AGAMOUS-like 16
AT3G57230.2AGAMOUS-like 16
AT3G57390.1AGAMOUS-like 18
AT3G58780.1MIKC_MADS family protein
AT3G58780.2MIKC_MADS family protein
AT3G58780.3MIKC_MADS family protein
AT3G61120.1AGAMOUS-like 13
AT4G09960.1MIKC_MADS family protein
AT4G09960.2MIKC_MADS family protein
AT4G09960.3MIKC_MADS family protein
AT4G09960.4MIKC_MADS family protein
AT4G11880.1AGAMOUS-like 14
AT4G18960.1MIKC_MADS family protein
AT4G22950.1AGAMOUS-like 19
AT4G24540.1AGAMOUS-like 24
AT4G37940.1AGAMOUS-like 21
AT5G10140.1MIKC_MADS family protein
AT5G10140.2MIKC_MADS family protein
AT5G10140.3MIKC_MADS family protein
AT5G10140.4MIKC_MADS family protein
AT5G13790.1AGAMOUS-like 15
AT5G15800.1MIKC_MADS family protein
AT5G15800.2MIKC_MADS family protein
AT5G20240.1MIKC_MADS family protein
AT5G23260.1MIKC_MADS family protein
AT5G23260.2MIKC_MADS family protein
AT5G23260.3MIKC_MADS family protein
AT5G51860.1MIKC_MADS family protein
AT5G51860.2MIKC_MADS family protein
AT5G51870.1AGAMOUS-like 71
AT5G51870.2AGAMOUS-like 71
AT5G51870.3AGAMOUS-like 71
AT5G60910.1AGAMOUS-like 8
AT5G62165.1AGAMOUS-like 42
AT5G62165.2AGAMOUS-like 42
AT5G62165.3AGAMOUS-like 42
AT5G62165.4AGAMOUS-like 42
AT5G65050.1AGAMOUS-like 31
AT5G65050.2AGAMOUS-like 31
AT5G65050.3AGAMOUS-like 31
AT5G65060.1MIKC_MADS family protein
AT5G65060.2MIKC_MADS family protein
AT5G65070.1MIKC_MADS family protein
AT5G65070.2MIKC_MADS family protein
AT5G65070.3MIKC_MADS family protein
AT5G65080.1MIKC_MADS family protein
AT5G65080.2MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513