PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Arabidopsis thaliana
ERF Family
Species TF ID Description
AT1G01250.1ERF family protein
AT1G03800.1ERF domain protein 10
AT1G04370.1Ethylene-responsive element binding factor 14
AT1G06160.1octadecanoid-responsive Arabidopsis AP2/ERF 59
AT1G12610.1ERF family protein
AT1G12630.1ERF family protein
AT1G12890.1ERF family protein
AT1G12980.1ERF family protein
AT1G15360.1ERF family protein
AT1G19210.1ERF family protein
AT1G21910.1ERF family protein
AT1G22190.1ERF family protein
AT1G22810.1ERF family protein
AT1G22985.1ERF family protein
AT1G24590.1DORNROSCHEN-like
AT1G25470.1ERF family protein
AT1G25470.2ERF family protein
AT1G28160.1ERF family protein
AT1G28360.1ERF domain protein 12
AT1G28370.1ERF domain protein 11
AT1G33760.1ERF family protein
AT1G36060.1ERF family protein
AT1G43160.1related to AP2 6
AT1G44830.1ERF family protein
AT1G46768.1related to AP2 1
AT1G49120.1ERF family protein
AT1G50640.1ethylene responsive element binding factor 3
AT1G53170.1ethylene response factor 8
AT1G53910.1related to AP2 12
AT1G53910.2related to AP2 12
AT1G53910.3related to AP2 12
AT1G63030.1ERF family protein
AT1G63030.2ERF family protein
AT1G64380.1ERF family protein
AT1G68550.1ERF family protein
AT1G68550.2ERF family protein
AT1G71130.1ERF family protein
AT1G71450.1ERF family protein
AT1G71520.1ERF family protein
AT1G72360.1ERF family protein
AT1G72360.2ERF family protein
AT1G72360.3ERF family protein
AT1G74930.1ERF family protein
AT1G75490.1ERF family protein
AT1G77200.1ERF family protein
AT1G77640.1ERF family protein
AT1G78080.1related to AP2 4
AT1G80580.1ERF family protein
AT2G20350.1ERF family protein
AT2G20880.1ERF family protein
AT2G22200.1ERF family protein
AT2G23340.1DREB and EAR motif protein 3
AT2G25820.1ERF family protein
AT2G31230.1ethylene-responsive element binding factor 15
AT2G33710.1ERF family protein
AT2G33710.2ERF family protein
AT2G35700.1ERF family protein
AT2G36450.1ERF family protein
AT2G38340.1ERF family protein
AT2G40220.1ERF family protein
AT2G40340.1ERF family protein
AT2G40350.1ERF family protein
AT2G44840.1ethylene-responsive element binding factor 13
AT2G44940.1ERF family protein
AT2G46310.1cytokinin response factor 5
AT2G47520.1ERF family protein
AT3G11020.1DRE/CRT-binding protein 2B
AT3G14230.1related to AP2 2
AT3G14230.2related to AP2 2
AT3G14230.3related to AP2 2
AT3G15210.1ethylene responsive element binding factor 4
AT3G16280.1ERF family protein
AT3G16770.1ethylene-responsive element binding protein
AT3G20310.1ethylene response factor 7
AT3G23220.1ERF family protein
AT3G23230.1ERF family protein
AT3G23240.1ethylene response factor 1
AT3G25890.1ERF family protein
AT3G25890.2ERF family protein
AT3G50260.1cooperatively regulated by ethylene and jasmonate 1
AT3G54320.2ERF family protein
AT3G57600.1ERF family protein
AT3G60490.1ERF family protein
AT3G61630.1cytokinin response factor 6
AT4G06746.1related to AP2 9
AT4G11140.1cytokinin response factor 1
AT4G13040.1ERF family protein
AT4G13040.2ERF family protein
AT4G13040.3ERF family protein
AT4G13620.1ERF family protein
AT4G16750.1ERF family protein
AT4G17490.1ethylene responsive element binding factor 6
AT4G17500.1ethylene responsive element binding factor 1
AT4G18450.1ERF family protein
AT4G23750.1cytokinin response factor 2
AT4G23750.2cytokinin response factor 2
AT4G25470.1C-repeat/DRE binding factor 2
AT4G25480.1dehydration response element B1A
AT4G25490.1C-repeat/DRE binding factor 1
AT4G27950.1cytokinin response factor 4
AT4G28140.1ERF family protein
AT4G31060.1ERF family protein
AT4G32800.1ERF family protein
AT4G34410.1redox responsive transcription factor 1
AT4G36900.1related to AP2 10
AT4G39780.1ERF family protein
AT5G05410.1DRE-binding protein 2A
AT5G05410.2DRE-binding protein 2A
AT5G07310.1ERF family protein
AT5G07580.1ERF family protein
AT5G11190.1ERF family protein
AT5G11590.1ERF family protein
AT5G13330.1related to AP2 6l
AT5G13910.1ERF family protein
AT5G18450.1ERF family protein
AT5G18560.1ERF family protein
AT5G19790.1related to AP2 11
AT5G21960.1ERF family protein
AT5G25190.1ERF family protein
AT5G25390.1ERF family protein
AT5G25390.2ERF family protein
AT5G25810.1ERF family protein
AT5G43410.1ERF family protein
AT5G44210.1erf domain protein 9
AT5G47220.1ethylene responsive element binding factor 2
AT5G47230.1ethylene responsive element binding factor 5
AT5G50080.1ethylene response factor 110
AT5G51190.1ERF family protein
AT5G51990.1C-repeat-binding factor 4
AT5G52020.1ERF family protein
AT5G53290.1cytokinin response factor 3
AT5G61590.1ERF family protein
AT5G61600.1ethylene response factor 104
AT5G61890.1ERF family protein
AT5G64750.1ERF family protein
AT5G65130.1ERF family protein
AT5G67000.1ERF family protein
AT5G67010.1ERF family protein
AT5G67190.1DREB and EAR motif protein 2
ERF Family Introduction

The AP2/ERF superfamily is defined by the AP2/ERF domain, which consists of about 60 to 70 amino acids and is involved in DNA binding. These three families have been defined as follows. The AP2 family proteins contain two repeated AP2/ERF domains, the ERF family proteins contain a single AP2/ERF domain, and the RAV family proteins contain a B3 domain, which is a DNA-binding domain conserved in other plant-specific transcription factors, in addition to the single AP2/ERF domain.

It has been demonstrated that the AP2/ERF proteins have important functions in the transcriptional regulation of a variety of biological processes related to growth and development, as well as various responses to environmental stimuli.

After finding the tobacco ERFs, many proteins in the ERF family were identified and implicated in many diverse functions in cellular processes, such as hormonal signal transduction, response to biotic and abiotic stresses, regulation of metabolism, and in developmental processes in various plant species.

Toshitsugu Nakano, Kaoru Suzuki, Tatsuhito Fujimura, and Hideaki Shinshi.
Genome-wide analysis of the ERF gene family in Arabidopsis and rice.
Plant Physiol, 2006. 140(2): p. 411-32.
PMID: 16407444


The first class are proteins which bind to ethylene response elements (ERE) or GCC boxes (tobacco EREBPs, Arabidopsis AtEBP and AtERF1-5, and tomato Pti4-6) found in the promoters of ethylene-inducible pathogenesis related genes. The GCC box is an 11 bp sequence (TAAGAGCCGCC) with a core GCCGCC sequence that is required for binding.
The second class includes proteins that bind to the C-repeat or dehydration response element (DRE) in the promoters of genes that are turned on in response to low temperatures and/or water deficit (CBF1, CBF2, CBF3/DREB1A and DREB2A). The C-repeat/DREs contain the core sequence CCGAC.

Nole-Wilson S, Krizek BA.
DNA binding properties of the Arabidopsis floral development protein AINTEGUMENTA.
Nucleic Acids Res. 2000 Nov 1;28(21):4076-82. Erratum in: Nucleic Acids Res 2001 Mar 1;29(5):1261.
PMID: 11058102