PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Arabidopsis lyrata
WRKY Family
Species TF ID Description
313633WRKY family protein
317082WRKY family protein
320036WRKY family protein
321760WRKY family protein
321761WRKY family protein
322266WRKY family protein
324601WRKY family protein
325325WRKY family protein
327396WRKY family protein
328547WRKY family protein
328625WRKY family protein
329038WRKY family protein
329411WRKY family protein
335144WRKY family protein
336031WRKY family protein
337643WRKY family protein
338870WRKY family protein
339216WRKY family protein
343891WRKY family protein
351629WRKY family protein
471557WRKY family protein
474956WRKY family protein
475116WRKY family protein
476056WRKY family protein
477161WRKY family protein
477731WRKY family protein
481313WRKY family protein
481352WRKY family protein
481938WRKY family protein
482446WRKY family protein
482718WRKY family protein
482857WRKY family protein
483604WRKY family protein
483794WRKY family protein
484242WRKY family protein
486080WRKY family protein
486325WRKY family protein
486738WRKY family protein
488124WRKY family protein
489268WRKY family protein
489657WRKY family protein
489946WRKY family protein
490404WRKY family protein
490447WRKY family protein
490719WRKY family protein
492487WRKY family protein
492514WRKY family protein
493050WRKY family protein
493831WRKY family protein
494337WRKY family protein
495347WRKY family protein
496697WRKY family protein
497253WRKY family protein
859664WRKY family protein
860504WRKY family protein
867069WRKY family protein
870142WRKY family protein
871269WRKY family protein
874313WRKY family protein
876639WRKY family protein
876849WRKY family protein
884073WRKY family protein
884135WRKY family protein
884150WRKY family protein
884408WRKY family protein
884549WRKY family protein
890619WRKY family protein
896042WRKY family protein
902048WRKY family protein
909483WRKY family protein
910251WRKY family protein
913314WRKY family protein
913892WRKY family protein
914166WRKY family protein
917333WRKY family protein
917334WRKY family protein
917932WRKY family protein
918771WRKY family protein
921120WRKY family protein
WRKY Family Introduction

WRKY transcription factors are one of the largest families of transcriptional regulators in plants and form integral parts of signalling webs that modulate many plant processes. Here, we review recent significant progress in WRKY transcription factor research. New findings illustrate that WRKY proteins often act as repressors as well as activators, and that members of the family play roles in both the repression and de-repression of important plant processes. Furthermore, it is becoming clear that a single WRKY transcription factor might be involved in regulating several seemingly disparate processes. Mechanisms of signalling and transcriptional regulation are being dissected, uncovering WRKY protein functions via interactions with a diverse array of protein partners, including MAP kinases, MAP kinase kinases, 14-3-3 proteins, calmodulin, histone deacetylases, resistance proteins and other WRKY transcription factors. WRKY genes exhibit extensive autoregulation and cross-regulation that facilitates transcriptional reprogramming in a dynamic web with built-in redundancy.

The defining feature of WRKY transcription factors is their DNA binding domain. This is called the WRKY domain after the almost invariant WRKY amino acid sequence at the N-terminus. In a few WRKY proteins, the WRKY amino acid sequences have been replaced by WRRY, WSKY, WKRY, WVKY or WKKY. The WRKY domain is about 60 residues in length, and as well as containing the WRKY signature it also has an atypical zinc-finger structure at the C-terminus. The zinc-finger structure is either Cx4-5Cx22-23HxH or Cx7Cx23HxC. Initially, in the absence of a complete gene family from any plant species, the WRKY transcription factors were divided into three groups based on the number of WRKY domains (two domains in Group I proteins and one in the others) and the structure of their zinc fingers (C2HC in Group III proteins).

Rushton PJ, Somssich IE, Ringler P, Shen QJ.
WRKY transcription factors.
Trends Plant Sci, 2010. 15(5): p. 247-58.
PMID: 20304701