PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Azadirachta indica
WOX Family
Species TF ID Description
Neem_29088_f_1WOX family protein
Neem_923_f_6WOX family protein
Neem_25663_f_1WOX family protein
Neem_7317_f_3WOX family protein
Neem_10483_f_2WOX family protein
Neem_24827_f_2WOX family protein
Neem_42804_f_1WOX family protein
Neem_14574_f_2WOX family protein
Neem_37811_f_1WOX family protein
Neem_6380_f_1WOX family protein
Neem_2949_f_14WOX family protein
Neem_3603_f_2WOX family protein
Neem_6964_f_1WOX family protein
Neem_22882_f_1WOX family protein
Neem_6707_f_3WOX family protein
Neem_8710_f_1WOX family protein
WOX Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401


The WOX genes form a plant-specific subclade of the eukaryotic homeobox transcription factor superfamily, which is characterized by the presence of a conserved DNA-binding homeodomain. The analysis of WOX gene expression and function shows that WOX family members fulfill specialized functions in key developmental processes in plants, such as embryonic patterning, stem-cell maintenance and organ formation. These functions can be related to either promotion of cell division activity and/or prevention of premature cell differentiation.

van der Graaff E, Laux T, Rensing SA.
The WUS homeobox-containing (WOX) protein family.
Genome Biol, 2009. 10(12): p. 248.
PMID: 20067590