PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Azadirachta indica
HD-ZIP Family
Species TF ID Description
Neem_21164_f_1HD-ZIP family protein
Neem_21693_f_1HD-ZIP family protein
Neem_5408_f_1HD-ZIP family protein
Neem_1266_f_5HD-ZIP family protein
Neem_28333_f_1HD-ZIP family protein
Neem_9814_f_1HD-ZIP family protein
Neem_13114_f_1HD-ZIP family protein
Neem_31326_f_1HD-ZIP family protein
Neem_4185_f_1HD-ZIP family protein
Neem_20262_f_1HD-ZIP family protein
Neem_20975_f_2HD-ZIP family protein
Neem_753_f_2HD-ZIP family protein
Neem_19092_f_1HD-ZIP family protein
Neem_40231_f_1HD-ZIP family protein
Neem_22284_f_3HD-ZIP family protein
Neem_5372_f_10HD-ZIP family protein
Neem_21804_f_1HD-ZIP family protein
Neem_615_f_5HD-ZIP family protein
Neem_25464_f_1HD-ZIP family protein
Neem_9905_f_2HD-ZIP family protein
Neem_1623_f_1HD-ZIP family protein
Neem_28142_f_1HD-ZIP family protein
Neem_31862_f_4HD-ZIP family protein
Neem_10226_f_1HD-ZIP family protein
Neem_13445_f_1HD-ZIP family protein
Neem_35923_f_1HD-ZIP family protein
Neem_1389_f_6HD-ZIP family protein
Neem_20836_f_1HD-ZIP family protein
Neem_24084_f_2HD-ZIP family protein
Neem_8352_f_2HD-ZIP family protein
Neem_18137_f_1HD-ZIP family protein
Neem_37527_f_1HD-ZIP family protein
Neem_877_f_2HD-ZIP family protein
Neem_628_f_5HD-ZIP family protein
Neem_1951_f_2HD-ZIP family protein
Neem_544_f_1HD-ZIP family protein
Neem_30069_f_1HD-ZIP family protein
Neem_3117_f_1HD-ZIP family protein
Neem_28382_f_1HD-ZIP family protein
Neem_11530_f_2HD-ZIP family protein
Neem_2214_f_1HD-ZIP family protein
Neem_19393_f_1HD-ZIP family protein
Neem_1512_f_1HD-ZIP family protein
Neem_27397_f_1HD-ZIP family protein
Neem_29055_f_1HD-ZIP family protein
Neem_11743_f_1HD-ZIP family protein
Neem_2892_f_3HD-ZIP family protein
Neem_9748_f_1HD-ZIP family protein
Neem_11133_f_6HD-ZIP family protein
Neem_19838_f_1HD-ZIP family protein
Neem_19919_f_1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401