PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Azadirachta indica
ERF Family
Species TF ID Description
Neem_10216_f_1ERF family protein
Neem_10606_f_1ERF family protein
Neem_10606_f_2ERF family protein
Neem_10606_f_3ERF family protein
Neem_11076_f_1ERF family protein
Neem_11103_f_1ERF family protein
Neem_11306_f_1ERF family protein
Neem_11306_f_2ERF family protein
Neem_11349_f_1ERF family protein
Neem_11593_f_1ERF family protein
Neem_14063_f_1ERF family protein
Neem_14380_f_1ERF family protein
Neem_14650_f_1ERF family protein
Neem_14718_f_1ERF family protein
Neem_15799_f_1ERF family protein
Neem_16726_f_1ERF family protein
Neem_1691_f_1ERF family protein
Neem_17301_f_1ERF family protein
Neem_1760_f_1ERF family protein
Neem_18885_f_1ERF family protein
Neem_19055_f_1ERF family protein
Neem_19062_f_1ERF family protein
Neem_19148_f_1ERF family protein
Neem_191_f_1ERF family protein
Neem_21512_f_1ERF family protein
Neem_21539_f_1ERF family protein
Neem_22394_f_2ERF family protein
Neem_2368_f_5ERF family protein
Neem_23750_f_1ERF family protein
Neem_25379_f_1ERF family protein
Neem_28524_f_2ERF family protein
Neem_28551_f_2ERF family protein
Neem_3101_f_1ERF family protein
Neem_32902_a_1ERF family protein
Neem_37611_f_1ERF family protein
Neem_3903_f_2ERF family protein
Neem_39295_f_1ERF family protein
Neem_42237_f_1ERF family protein
Neem_4567_f_1ERF family protein
Neem_4610_f_1ERF family protein
Neem_4688_a_2ERF family protein
Neem_4688_f_1ERF family protein
Neem_5009_f_1ERF family protein
Neem_5122_f_1ERF family protein
Neem_5658_f_1ERF family protein
Neem_576_f_7ERF family protein
Neem_5920_f_4ERF family protein
Neem_6466_f_3ERF family protein
Neem_6825_f_1ERF family protein
Neem_7113_f_1ERF family protein
Neem_7405_f_3ERF family protein
Neem_8102_f_3ERF family protein
Neem_8170_f_1ERF family protein
Neem_8330_a_1ERF family protein
Neem_876_f_4ERF family protein
Neem_9151_f_2ERF family protein
Neem_923_f_7ERF family protein
Neem_9565_f_3ERF family protein
Neem_9604_f_1ERF family protein
Neem_9889_f_1ERF family protein
Neem_9993_f_1ERF family protein
ERF Family Introduction

The AP2/ERF superfamily is defined by the AP2/ERF domain, which consists of about 60 to 70 amino acids and is involved in DNA binding. These three families have been defined as follows. The AP2 family proteins contain two repeated AP2/ERF domains, the ERF family proteins contain a single AP2/ERF domain, and the RAV family proteins contain a B3 domain, which is a DNA-binding domain conserved in other plant-specific transcription factors, in addition to the single AP2/ERF domain.

It has been demonstrated that the AP2/ERF proteins have important functions in the transcriptional regulation of a variety of biological processes related to growth and development, as well as various responses to environmental stimuli.

After finding the tobacco ERFs, many proteins in the ERF family were identified and implicated in many diverse functions in cellular processes, such as hormonal signal transduction, response to biotic and abiotic stresses, regulation of metabolism, and in developmental processes in various plant species.

Toshitsugu Nakano, Kaoru Suzuki, Tatsuhito Fujimura, and Hideaki Shinshi.
Genome-wide analysis of the ERF gene family in Arabidopsis and rice.
Plant Physiol, 2006. 140(2): p. 411-32.
PMID: 16407444


The first class are proteins which bind to ethylene response elements (ERE) or GCC boxes (tobacco EREBPs, Arabidopsis AtEBP and AtERF1-5, and tomato Pti4-6) found in the promoters of ethylene-inducible pathogenesis related genes. The GCC box is an 11 bp sequence (TAAGAGCCGCC) with a core GCCGCC sequence that is required for binding.
The second class includes proteins that bind to the C-repeat or dehydration response element (DRE) in the promoters of genes that are turned on in response to low temperatures and/or water deficit (CBF1, CBF2, CBF3/DREB1A and DREB2A). The C-repeat/DREs contain the core sequence CCGAC.

Nole-Wilson S, Krizek BA.
DNA binding properties of the Arabidopsis floral development protein AINTEGUMENTA.
Nucleic Acids Res. 2000 Nov 1;28(21):4076-82. Erratum in: Nucleic Acids Res 2001 Mar 1;29(5):1261.
PMID: 11058102