PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Azadirachta indica
E2F/DP Family
Species TF ID Description
Neem_1088_f_4E2F/DP family protein
Neem_11537_f_2E2F/DP family protein
Neem_11616_f_3E2F/DP family protein
Neem_25150_f_1E2F/DP family protein
Neem_29359_f_1E2F/DP family protein
Neem_37436_f_1E2F/DP family protein
Neem_39617_f_1E2F/DP family protein
Neem_6527_f_1E2F/DP family protein
Neem_7267_f_1E2F/DP family protein
Neem_8393_f_1E2F/DP family protein
E2F/DP Family Introduction

E2F transcription factors are a family of proteins that share a related DNA-binding domain and that bind to overlapping sets of target promoters. Most E2F proteins associate with a DP protein and form heterodimeric complexes that bind to DNA in a sequence-specific manner. E2F proteins control the temporal expression of genes that are needed for multiple processes during the cell cycle. Consequently, the level of E2F-dependent transcription is important for cell proliferation.

Different types of E2F complexes either activate or repress transcription. E2F repressor complexes suppress the transcription of their targets in quiescent cells, in differentiated cells and during the G1 phase of the cell cycle. When cells enter the cell cycle and proliferate, these repressors are disrupted and/or replaced by activator forms of E2F that promote gene expression.

van den Heuvel S, Dyson NJ.
Conserved functions of the pRB and E2F families.
Nat Rev Mol Cell Biol, 2008. 9(9): p. 713-24.
PMID: 18719710