PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Azadirachta indica
AP2 Family
Species TF ID Description
Neem_17075_f_1AP2 family protein
Neem_22260_f_1AP2 family protein
Neem_24334_f_1AP2 family protein
Neem_3422_f_3AP2 family protein
Neem_38613_f_1AP2 family protein
Neem_39575_f_1AP2 family protein
Neem_5261_f_1AP2 family protein
Neem_7232_f_2AP2 family protein
Neem_944_f_6AP2 family protein
Neem_1536_f_4AP2 family protein
Neem_905_f_2AP2 family protein
Neem_392_f_1AP2 family protein
Neem_14209_f_1AP2 family protein
Neem_2227_f_5AP2 family protein
Neem_2052_f_1AP2 family protein
Neem_32272_f_1AP2 family protein
Neem_5877_f_5AP2 family protein
Neem_9515_f_1AP2 family protein
Neem_15903_f_1AP2 family protein
Neem_8505_f_4AP2 family protein
Neem_23068_f_1AP2 family protein
Neem_20155_f_1AP2 family protein
Neem_8648_f_1AP2 family protein
AP2 Family Introduction

The AP2/ERF superfamily is defined by the AP2/ERF domain, which consists of about 60 to 70 amino acids and is involved in DNA binding. These three families have been defined as follows. The AP2 family proteins contain two repeated AP2/ERF domains, the ERF family proteins contain a single AP2/ERF domain, and the RAV family proteins contain a B3 domain, which is a DNA-binding domain conserved in other plant-specific transcription factors, in addition to the single AP2/ERF domain.

It has been demonstrated that the AP2/ERF proteins have important functions in the transcriptional regulation of a variety of biological processes related to growth and development, as well as various responses to environmental stimuli.

Genes in the AP2 family have been shown to participate in the regulation of developmental processes, e.g. flower development, spikelet meristem determinacy, leaf epidermal cell identity, and embryo development.

Toshitsugu Nakano, Kaoru Suzuki, Tatsuhito Fujimura, and Hideaki Shinshi.
Genome-wide analysis of the ERF gene family in Arabidopsis and rice.
Plant Physiol, 2006. 140(2): p. 411-32.
PMID: 16407444

Using an in vitro selection procedure, the DNA binding specificity of the two AP2 repeat containing protein ANT was found to be 5'-gCAC(A/G)N(A/T)TcCC(a/g)ANG(c/t)-3'. This consensus site is much longer than sites recognized by proteins containing a single AP2 repeat and neither AP2 repeat of ANT was alone capable of binding to the selected sequences, suggesting that both AP2 repeats make DNA contacts.

Nole-Wilson S, Krizek BA.
DNA binding properties of the Arabidopsis floral development protein AINTEGUMENTA.
Nucleic Acids Res. 2000 Nov 1;28(21):4076-82. Erratum in: Nucleic Acids Res 2001 Mar 1;29(5):1261.
PMID: 11058102