PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Amaranthus hypochondriacus
WRKY Family
Species TF ID Description
AHYPO_000293-RAWRKY family protein
AHYPO_000361-RAWRKY family protein
AHYPO_001457-RAWRKY family protein
AHYPO_001471-RAWRKY family protein
AHYPO_001767-RAWRKY family protein
AHYPO_002079-RAWRKY family protein
AHYPO_002926-RAWRKY family protein
AHYPO_002927-RAWRKY family protein
AHYPO_002929-RAWRKY family protein
AHYPO_003251-RAWRKY family protein
AHYPO_003441-RAWRKY family protein
AHYPO_003717-RAWRKY family protein
AHYPO_004291-RAWRKY family protein
AHYPO_004688-RAWRKY family protein
AHYPO_004797-RAWRKY family protein
AHYPO_004901-RAWRKY family protein
AHYPO_004903-RAWRKY family protein
AHYPO_004956-RAWRKY family protein
AHYPO_005243-RAWRKY family protein
AHYPO_005288-RAWRKY family protein
AHYPO_005291-RAWRKY family protein
AHYPO_006747-RAWRKY family protein
AHYPO_006832-RAWRKY family protein
AHYPO_007084-RAWRKY family protein
AHYPO_007097-RAWRKY family protein
AHYPO_008379-RAWRKY family protein
AHYPO_008645-RAWRKY family protein
AHYPO_008672-RAWRKY family protein
AHYPO_008723-RAWRKY family protein
AHYPO_008983-RAWRKY family protein
AHYPO_009078-RAWRKY family protein
AHYPO_010169-RAWRKY family protein
AHYPO_010277-RAWRKY family protein
AHYPO_012623-RAWRKY family protein
AHYPO_012684-RAWRKY family protein
AHYPO_012959-RAWRKY family protein
AHYPO_013633-RAWRKY family protein
AHYPO_014049-RAWRKY family protein
AHYPO_014407-RAWRKY family protein
AHYPO_014705-RAWRKY family protein
AHYPO_014915-RAWRKY family protein
AHYPO_015016-RAWRKY family protein
AHYPO_015218-RAWRKY family protein
AHYPO_015626-RAWRKY family protein
AHYPO_015670-RAWRKY family protein
AHYPO_015965-RAWRKY family protein
AHYPO_016181-RAWRKY family protein
AHYPO_016561-RAWRKY family protein
AHYPO_017174-RAWRKY family protein
AHYPO_017558-RAWRKY family protein
AHYPO_018419-RAWRKY family protein
AHYPO_020001-RAWRKY family protein
AHYPO_021134-RAWRKY family protein
AHYPO_022227-RAWRKY family protein
WRKY Family Introduction

WRKY transcription factors are one of the largest families of transcriptional regulators in plants and form integral parts of signalling webs that modulate many plant processes. Here, we review recent significant progress in WRKY transcription factor research. New findings illustrate that WRKY proteins often act as repressors as well as activators, and that members of the family play roles in both the repression and de-repression of important plant processes. Furthermore, it is becoming clear that a single WRKY transcription factor might be involved in regulating several seemingly disparate processes. Mechanisms of signalling and transcriptional regulation are being dissected, uncovering WRKY protein functions via interactions with a diverse array of protein partners, including MAP kinases, MAP kinase kinases, 14-3-3 proteins, calmodulin, histone deacetylases, resistance proteins and other WRKY transcription factors. WRKY genes exhibit extensive autoregulation and cross-regulation that facilitates transcriptional reprogramming in a dynamic web with built-in redundancy.

The defining feature of WRKY transcription factors is their DNA binding domain. This is called the WRKY domain after the almost invariant WRKY amino acid sequence at the N-terminus. In a few WRKY proteins, the WRKY amino acid sequences have been replaced by WRRY, WSKY, WKRY, WVKY or WKKY. The WRKY domain is about 60 residues in length, and as well as containing the WRKY signature it also has an atypical zinc-finger structure at the C-terminus. The zinc-finger structure is either Cx4-5Cx22-23HxH or Cx7Cx23HxC. Initially, in the absence of a complete gene family from any plant species, the WRKY transcription factors were divided into three groups based on the number of WRKY domains (two domains in Group I proteins and one in the others) and the structure of their zinc fingers (C2HC in Group III proteins).

Rushton PJ, Somssich IE, Ringler P, Shen QJ.
WRKY transcription factors.
Trends Plant Sci, 2010. 15(5): p. 247-58.
PMID: 20304701