PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Aquilegia coerulea
HD-ZIP Family
Species TF ID Description
Aqcoe3G294900.1.pHD-ZIP family protein
Aqcoe3G325400.1.pHD-ZIP family protein
Aqcoe0069s0001.1.pHD-ZIP family protein
Aqcoe6G076600.1.pHD-ZIP family protein
Aqcoe6G076600.2.pHD-ZIP family protein
Aqcoe3G332700.2.pHD-ZIP family protein
Aqcoe3G332700.1.pHD-ZIP family protein
Aqcoe3G085900.2.pHD-ZIP family protein
Aqcoe3G085900.3.pHD-ZIP family protein
Aqcoe3G115700.1.pHD-ZIP family protein
Aqcoe3G085900.4.pHD-ZIP family protein
Aqcoe3G085900.1.pHD-ZIP family protein
Aqcoe3G272100.1.pHD-ZIP family protein
Aqcoe1G013600.1.pHD-ZIP family protein
Aqcoe6G318600.1.pHD-ZIP family protein
Aqcoe5G096200.1.pHD-ZIP family protein
Aqcoe7G002200.1.pHD-ZIP family protein
Aqcoe5G096100.1.pHD-ZIP family protein
Aqcoe1G115900.2.pHD-ZIP family protein
Aqcoe1G115900.1.pHD-ZIP family protein
Aqcoe5G197900.1.pHD-ZIP family protein
Aqcoe3G016600.2.pHD-ZIP family protein
Aqcoe3G016600.1.pHD-ZIP family protein
Aqcoe1G251700.1.pHD-ZIP family protein
Aqcoe6G111300.1.pHD-ZIP family protein
Aqcoe7G306400.1.pHD-ZIP family protein
Aqcoe7G170900.1.pHD-ZIP family protein
Aqcoe4G229400.1.pHD-ZIP family protein
Aqcoe1G352400.1.pHD-ZIP family protein
Aqcoe7G043700.1.pHD-ZIP family protein
Aqcoe7G043700.2.pHD-ZIP family protein
Aqcoe7G043700.3.pHD-ZIP family protein
Aqcoe3G009800.1.pHD-ZIP family protein
Aqcoe7G157600.2.pHD-ZIP family protein
Aqcoe7G157600.1.pHD-ZIP family protein
Aqcoe7G157600.3.pHD-ZIP family protein
Aqcoe7G157600.4.pHD-ZIP family protein
Aqcoe1G178700.1.pHD-ZIP family protein
Aqcoe3G168400.1.pHD-ZIP family protein
Aqcoe1G143700.1.pHD-ZIP family protein
Aqcoe1G143700.2.pHD-ZIP family protein
Aqcoe3G406600.1.pHD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401