PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Ananas comosus
HD-ZIP Family
Species TF ID Description
Aco023084.1HD-ZIP family protein
Aco002761.1HD-ZIP family protein
Aco014788.1HD-ZIP family protein
Aco020633.1HD-ZIP family protein
Aco001141.1HD-ZIP family protein
Aco004061.1HD-ZIP family protein
Aco000178.1HD-ZIP family protein
Aco012846.1HD-ZIP family protein
Aco027420.1HD-ZIP family protein
Aco014364.1HD-ZIP family protein
Aco006154.1HD-ZIP family protein
Aco015133.1HD-ZIP family protein
Aco000939.1HD-ZIP family protein
Aco005425.1HD-ZIP family protein
Aco024127.1HD-ZIP family protein
Aco003777.1HD-ZIP family protein
Aco007497.1HD-ZIP family protein
Aco029320.1HD-ZIP family protein
Aco013357.1HD-ZIP family protein
Aco004982.1HD-ZIP family protein
Aco007423.1HD-ZIP family protein
Aco018124.1HD-ZIP family protein
Aco015577.1HD-ZIP family protein
Aco013825.1HD-ZIP family protein
Aco008460.1HD-ZIP family protein
Aco015166.1HD-ZIP family protein
Aco002636.1HD-ZIP family protein
Aco007722.1HD-ZIP family protein
Aco001366.1HD-ZIP family protein
Aco005080.1HD-ZIP family protein
Aco008700.1HD-ZIP family protein
Aco017307.1HD-ZIP family protein
Aco009064.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401