PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Actinidia chinensis
HD-ZIP Family
Species TF ID Description
Achn229211HD-ZIP family protein
Achn157531HD-ZIP family protein
Achn143971HD-ZIP family protein
Achn234471HD-ZIP family protein
Achn323811HD-ZIP family protein
Achn141491HD-ZIP family protein
Achn238371HD-ZIP family protein
Achn366091HD-ZIP family protein
Achn304551HD-ZIP family protein
Achn217881HD-ZIP family protein
Achn378471HD-ZIP family protein
Achn048321HD-ZIP family protein
Achn124741HD-ZIP family protein
Achn002881HD-ZIP family protein
Achn324431HD-ZIP family protein
Achn225201HD-ZIP family protein
Achn222511HD-ZIP family protein
Achn246921HD-ZIP family protein
Achn295401HD-ZIP family protein
Achn210611HD-ZIP family protein
Achn183171HD-ZIP family protein
Achn265441HD-ZIP family protein
Achn063681HD-ZIP family protein
Achn387871HD-ZIP family protein
Achn090901HD-ZIP family protein
Achn090891HD-ZIP family protein
Achn080611HD-ZIP family protein
Achn149691HD-ZIP family protein
Achn044651HD-ZIP family protein
Achn046891HD-ZIP family protein
Achn043381HD-ZIP family protein
Achn133091HD-ZIP family protein
Achn086361HD-ZIP family protein
Achn389601HD-ZIP family protein
Achn092131HD-ZIP family protein
Achn254421HD-ZIP family protein
Achn345501HD-ZIP family protein
Achn282711HD-ZIP family protein
Achn190371HD-ZIP family protein
Achn174081HD-ZIP family protein
Achn023811HD-ZIP family protein
Achn354821HD-ZIP family protein
Achn364271HD-ZIP family protein
Achn126071HD-ZIP family protein
Achn198951HD-ZIP family protein
Achn257441HD-ZIP family protein
Achn326311HD-ZIP family protein
Achn375621HD-ZIP family protein
Achn302451HD-ZIP family protein
Achn111511HD-ZIP family protein
Achn384901HD-ZIP family protein
Achn007121HD-ZIP family protein
Achn276751HD-ZIP family protein
Achn216491HD-ZIP family protein
Achn054811HD-ZIP family protein
Achn049821HD-ZIP family protein
Achn162391HD-ZIP family protein
Achn003171HD-ZIP family protein
Achn043311HD-ZIP family protein
Achn307731HD-ZIP family protein
Achn081891HD-ZIP family protein
Achn250041HD-ZIP family protein
Achn313451HD-ZIP family protein
Achn108861HD-ZIP family protein
Achn203981HD-ZIP family protein
Achn081091HD-ZIP family protein
Achn060231HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401