PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Artemisia annua
bZIP Family
Species TF ID Description
Aan000253bZIP family protein
Aan000705bZIP family protein
Aan001056bZIP family protein
Aan001901bZIP family protein
Aan002490bZIP family protein
Aan004256bZIP family protein
Aan004553bZIP family protein
Aan004602bZIP family protein
Aan004728bZIP family protein
Aan005267bZIP family protein
Aan005880bZIP family protein
Aan006092bZIP family protein
Aan007225bZIP family protein
Aan008028bZIP family protein
Aan008454bZIP family protein
Aan008724bZIP family protein
Aan010275bZIP family protein
Aan010772bZIP family protein
Aan010782bZIP family protein
Aan011380bZIP family protein
Aan011944bZIP family protein
Aan013639bZIP family protein
Aan014407bZIP family protein
Aan015469bZIP family protein
Aan015696bZIP family protein
Aan016078bZIP family protein
Aan016079bZIP family protein
Aan016969bZIP family protein
Aan017911bZIP family protein
Aan018607bZIP family protein
Aan019471bZIP family protein
Aan019530bZIP family protein
Aan019831bZIP family protein
Aan020139bZIP family protein
Aan021079bZIP family protein
bZIP Family Introduction

The bZIP domain consists of two structural features located on a contiguous alpha-helix: first, a basic region of ~ 16 amino acid residues containing a nuclear localization signal followed by an invariant N-x7-R/K motif that contacts the DNA; and, second, a heptad repeat of leucines or other bulky hydrophobic amino acids positioned exactly nine amino acids towards the C-terminus, creating an amphipathic helix. To bind DNA, two subunits adhere via interactions between the hydrophobic sides of their helices, which creates a superimposing coiled-coil structure. The ability to form homo- and heterodimers is influenced by the electrostatic attraction and repulsion of polar residues flanking the hydrophobic interaction surface of the helices.

Plant bZIP proteins preferentially bind to DNA sequences with an ACGT core. Binding specificity is regulated by flanking nucleotides. Plant bZIPs preferentially bind to the A-box (TACGTA), C-box (GACGTC) and G-box (CACGTG), but there are also examples of nonpalindromic binding sites.

Jakoby M, Weisshaar B, Droge-Laser W, Vicente-Carbajosa J, Tiedemann J, Kroj T, Parcy F
bZIP transcription factors in Arabidopsis.
Trends Plant Sci, 2002. 7(3): p. 106-11.
PMID: 11906833