PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Arabis alpina
HD-ZIP Family
Species TF ID Description
KFK37614.1HD-ZIP family protein
KFK37613.1HD-ZIP family protein
KFK41389.1HD-ZIP family protein
KFK32818.1HD-ZIP family protein
KFK25752.1HD-ZIP family protein
KFK30396.1HD-ZIP family protein
KFK25083.1HD-ZIP family protein
KFK37583.1HD-ZIP family protein
KFK37287.1HD-ZIP family protein
KFK22263.1HD-ZIP family protein
KFK35246.1HD-ZIP family protein
KFK32790.1HD-ZIP family protein
KFK30389.1HD-ZIP family protein
KFK44605.1HD-ZIP family protein
KFK24548.1HD-ZIP family protein
KFK37424.1HD-ZIP family protein
KFK28350.1HD-ZIP family protein
KFK31383.1HD-ZIP family protein
KFK33134.1HD-ZIP family protein
KFK40239.1HD-ZIP family protein
KFK40238.1HD-ZIP family protein
KFK33368.1HD-ZIP family protein
KFK35376.1HD-ZIP family protein
KFK29142.1HD-ZIP family protein
KFK24840.1HD-ZIP family protein
KFK40728.1HD-ZIP family protein
KFK36538.1HD-ZIP family protein
KFK27013.1HD-ZIP family protein
KFK42389.1HD-ZIP family protein
KFK36372.1HD-ZIP family protein
KFK37365.1HD-ZIP family protein
KFK35314.1HD-ZIP family protein
KFK44860.1HD-ZIP family protein
KFK27595.1HD-ZIP family protein
KFK41777.1HD-ZIP family protein
KFK30661.1HD-ZIP family protein
KFK23374.1HD-ZIP family protein
KFK23375.1HD-ZIP family protein
KFK29053.1HD-ZIP family protein
KFK37767.1HD-ZIP family protein
KFK41558.1HD-ZIP family protein
KFK23373.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401